The humble marine sandworm may help in the hunt for a new class of antibioticsafter University of Queensland researchers improved a molecule in the sand-dwelling animal which kills superbugs.

UQ’s Institute for Molecular Bioscience researcher Dr Alysha Elliott said thestudy assessed peptides inspired by natural antibiotics in sandworms to see ifthey could kill multi-drug resistant strains of bacteria.

“A Danish biotechnology company asked for our help to investigate a smallpeptide called arenicin-3 that they found in the marine sandworm Arenicolamarina, which could kill Gram-negative bacteria — including strains resistantto last-resort antibiotics,” Dr Elliott said

“Gram-negative bacteria have evolved to outsmart our current antibiotics, butnatural antibiotics like the one found in the sandworm can penetrate the cellmembrane of bacteria.”

Dr Elliott said Gram-negative bacteria were more difficult to kill due to anadditional sophisticated line of defence in their membranes.

Arenicola marina, commonly known as the marine sandworm on the beach. Image:© Professor Matt Cooper/The University of Queensland.

UQ IMB scientists Dr Alysha Elliott and Dr Johnny Huang were part of theresearch team led by Professor Matt Cooper that tested arenicin-3 and newcompounds inspired by the marine sandworm.

“While many of the initial compounds were remarkably active in killing thebacteria, they were toxic to human cells including red blood cells, and didnot work well in the presence of lung surfactant,” Dr Huang said.

A close-up shot of the lugworm in the hand of Dr Elliott. Image: © ProfessorMatt Cooper/The University of Queensland.

“This would be an issue if we wanted to treat bacterial pneumonia where theinfection is found in the lung.”

The researchers kept tweaking the structure of the peptide and succeeded indeveloping AA139 that could kill multi-drug resistant bacteria in many modelsof disease, with far fewer side effects.

“Our next challenge is to get this peptide to where the infections are found,”Dr Elliott said.

“Many bacterial infections are deep-seated, requiring penetration throughtissue to reach them. This is a tough challenge for a peptide antibiotic,although there remains a dire unmet medical need for new antibiotics.”

Main Image – Arenicola marina, commonly known as the marine sandworm on thebeach. Image: © Professor Matt Cooper/The University of Queensland.

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